Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
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چکیده
منابع مشابه
Regulation of Autophagy by the Neuropathological Protein Tdp-43
NEUROPATHOLOGICAL PROTEIN TDP-43 Jayarama Krishnan Bose, Chi-Chen Huang and C.-K. James Shen Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China Running head: TDP-43 and Autophagy Address correspondence to: C.-K. James Shen, PhD, N523, Institute of Molecular Biology, Academia Sinica, 128 Academia Road, Sec 2, Nangang, Taipei-115, Taiwan, ROC. Tel: +886-2-2789-9194...
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TAR DNA-binding protein 43 (TDP-43) is a major component in aggregates of ubiquitinated proteins in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we report that lipopolysaccharide (LPS)-induced inflammation can promote TDP-43 mislocalization and aggregation. In culture, microglia and astrocytes exhibited TDP-43 mislocalization after exposure to LPS. Like...
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Aggregation of TAR-DNA-binding protein 43 (TDP-43) and of its fragments TDP-25 and TDP-35 occurs in amyotrophic lateral sclerosis (ALS). TDP-25 and TDP-35 act as seeds for TDP-43 aggregation, altering its function and exerting toxicity. Thus, inhibition of TDP-25 and TDP-35 aggregation and promotion of their degradation may protect against cellular damage. Upregulation of HSPB8 is one possible ...
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TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing. Intracellular aggregation of TDP-43 is a hallmark of amyotrophic lateral sclerosis and ubiquitin-positive frontotemporal lobar degeneration. This TDP-43 pathology is also present in other types of neurodege...
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The aggregation of TAR DNA-binding protein (TDP-43) has been shown as a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) since 2006. While evidence has suggested that mutation or truncation in TDP-43 influences its aggregation process, nevertheless, the correlation between the TDP-43 aggregation propensity and its binding substrates has not been fully...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2020
ISSN: 1662-5099
DOI: 10.3389/fnmol.2020.00019